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Vascular Pericytes to Support Vessel Function and Tumor Growth Lin Cheng,1,7 Zhi Huang,1,7 Wenchao Zhou,1 Qiulian Wu,1 Shannon Donnola,1 James K. Liu,2 Xiaoguang Fang,1 Andrew E. Sloan,3 Yubin Mao,4 Justin D. Lathia,1 Wang Min,5 Roger E. McLendon,6 Jeremy N. Rich,1 and Shideng Bao1,* The brain pericytes function as oxygen sensors and respond to hypoxia. They are regulated by hypoxia-inducible factor (HIF)-2 and prolyl-4-hydroxylase (PHD) 2 and 3. 1 View large Download PPT In essence, pericytes seem important as structural support in the microcirculation and in BBB function. Pericytes have been considered to be significant in the pathogenesis of tissue damage in hypoxia, hypertension, diabetic retinopathy, trauma, Alzheimer’s disease, multiple sclerosis, and in CNS tumor formation [7, 12 13 14]. It is generally thought that CCL2 is produced by astrocytes, resident microglia, infiltrating macrophages, and, to a lesser extent, endothelial cells in the brain.

Pericytes function

Pericytes are also emerging as therapeutic targets in pathological conditions such as tissue fibrosis, stroke, and tumors. The vast array of pericyte functions include contractility, immunologic, migratory, and angiogenic. Pericytes have stem cell potential, contribute to the integrity of the blood-brain barrier, and have a regulatory role for hemostasis in the brain. Pericytes—dainty little cells that decorate the brain’s smallest blood vessels— are drawing growing research interest, and controversy.

PDGF, Pericytes and the Pathogenesis of Idiopathic Basal Ganglia

DNA precursor biosynthesis-allosteric regulation and medical applications · 2. The Role of Microvascular Pericytes in the Generation of Pro-fibrotic Connective The role of regulatory T cell (Treg) in pediatric nonHodgkin's and Hodgkin's The role of microvascular pericytes and fibrosis in tumor stroma formation. av J Schuck · 2000 · Citerat av 32 — During the past years, the functional role of glial cells has evoked these vessels were accompanied by pericytes and their slender processes. Function and regulation of a cancer-associated remodeler Targeting pericyte-mediated immunosuppression in Glioblastoma multiforme.

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Abstract Pericytes are vascular mural cells embedded in the basement membrane of blood microvessels. They extend their processes along capillaries, pre-capillary arterioles and post-capillary More recently, numerous vascular functions of pericytes have been identified including regulation of cerebral blood flow, maintenance of the blood-brain barrier (BBB), and control of vascular development and angiogenesis. Pericytes can also facilitate neuroinflammatory processes and possess stem cell-like properties. Abstract Pericytes are vascular mural cells embedded in the basement membrane of blood microvessels. They extend their processes along capillaries, pre-capillary arterioles and post-capillary Pericytes: characterization, function and dysfunction Characterization. Pericytes are embedded in the basement membrane of small blood vessels including capillaries, pre-capillary arterioles and post-capillary venules2.

4 –6 Pericytes regulate central nervous system (CNS) blood flow at the level of capillaries providing neuronal coupling with the NVU. 7 CNS microvessels have a ratio of pericytes to endothelial cells that is higher when compared to organs with Pericytes are versatile and their varying morphological characteristics and distribution make them difficult to study. The lack of universal pericytes markers is a major problem.
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For one, whether these cells help control cerebral blood flow has been a contentious issue, with different groups reporting conflicting data. Pericytes (PCs) ─ mural cells that envelop endothelial cells (ECs) of microvessels ─ regulate tissue‐specific vasculature development as well as maturation and maintenance of endothelial barrier Pericytes expressing apoE4 (apolipoprotein E4) are less efficient in supporting endothelial cell function because of their diminished property to induce extracellular matrix production and barrier formation compared with those expressing apoE3 in vitro. As an important component of vascular tubes, pericytes exhibit myriad different functions, such as vessel stabilization, multiple‐lineage differentiation capacity, and angiogenic stimulation (1). These functions, however, are highly variable and diverse in different tissues/organs and developmental stages.

Transplanting pericytes into host muscle causes them to fuse with myoblasts to form myotubes, which helps to regenerate muscle in cases of injury or necrosis.
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Functions of Pericytes in Ischemic Stroke - Lunds universitet

Pancreatic Pericytes Express the Transcription Factor Tcf7l2 We recently showed that pericytes support b-cell function (21). Here, we set to elucidate the molecular basis of pericyte activity. To this end, we used the Nkx3.2-Cre mouse line 438 Pericytic Tcf7l2 in b-Cell Function Diabetes Volume 67, March 2018 Pericytes wrapped around brain microvascular endothelial cells (BMVEC) on the “brain side” provide support for endothelial barrier function. 4 –6 Pericytes regulate central nervous system (CNS) blood flow at the level of capillaries providing neuronal coupling with the NVU. 7 CNS microvessels have a ratio of pericytes to endothelial cells that is higher when compared to organs with Pericytes are versatile and their varying morphological characteristics and distribution make them difficult to study. The lack of universal pericytes markers is a major problem. A number of different functions have been attributed to pericytes, and in some organs they have more specific roles. 2.